Found: The dial in the brain that controls the immune system

https://www.nature.com/articles/d41586-024-01259-2

Scientists have long known that the brain plays a part in the immune system — but how it does so has been a mystery. Now, scientists have identified cells in the brainstem that sense immune cues from the periphery of the body and act as master regulators of the body’s inflammatory response.

Access options

Access Nature and 54 other Nature Portfolio journals

Get Nature+, our best-value online-access subscription

$32.99 / 30 days

cancel any time

Subscribe to this journal

Receive 51 print issues and online access

$199.00 per year

only $3.90 per issue

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Additional access options:

doi: https://doi.org/10.1038/d41586-024-01259-2

References

Subjects

Latest on:

Nature Careers

Jobs

  • Postdoctoral Fellow

    Postdoctoral Fellow focus on ferroic smart materials: shape-memory alloys, piezoelectric ceramics, and magnetostrictive materials, etc

    Ningbo, Zhejiang (CN)

    Center for Advanced Smart Materials (CASM), Yongjiang Laboratory (Y-Lab)

  • Principal Investigator/ Associate Professor

    PI & Associate Professor class focus on innovative research about ferroic smart materials or technology transfer

    Ningbo, Zhejiang (CN)

    Center for Advanced Smart Materials (CASM), Yongjiang Laboratory (Y-Lab)

  • Scientific Editor

    The Scientific Editor plays a critical role in ensuring a high‑quality, efficient, and integrity‑driven peer review process.

    London - Hybrid working model

    Springer Nature Ltd

  • CRAG Director

    CRAG is seeking applicants for Director with a distinguished record of scientific excellence, proven leadership and management experience.

    Universitat Autònoma de Barcelona (UAB), Bellaterra, Barcelona

    Centre de Recerca en Agrigenòmica (CRAG), Consorci CSIC – IRTA – UAB – UB

  • Associate or Senior Editor, Nature Materials

    Job Title: Associate or Senior Editor, Nature Materials Locations: Shanghai, Beijing, Milan or Pune - hybrid working model Application Deadline: Ju...

    Shanghai, Beijing, Milan or Pune - hybrid working model

    Springer Nature Ltd

{
"by": "andreareina",
"descendants": 4,
"id": 40243417,
"kids": [
40243718,
40244904,
40245202
],
"score": 45,
"time": 1714703500,
"title": "Found: The dial in the brain that controls the immune system",
"type": "story",
"url": "https://www.nature.com/articles/d41586-024-01259-2"
}
{
"author": "Giorgia Guglielmi",
"date": "2024-05-01T00:00:00.000Z",
"description": "Scientists identify the brain cells that regulate inflammation, and pinpoint how they keep tabs on the immune response.",
"image": "https://media.nature.com/lw1200/magazine-assets/d41586-024-01259-2/d41586-024-01259-2_27034294.jpg",
"logo": null,
"publisher": "Nature",
"title": "Found: the dial in the brain that controls the immune system",
"url": "https://www.nature.com/articles/d41586-024-01259-2"
}
{
"url": "https://www.nature.com/articles/d41586-024-01259-2",
"title": "Found: the dial in the brain that controls the immune system",
"description": "Scientists identify the brain cells that regulate inflammation, and pinpoint how they keep tabs on the immune response. Scientists identify the brain cells that regulate inflammation, and pinpoint how they keep tabs on the immune response.",
"links": [
"https://www.nature.com/articles/d41586-024-01259-2"
],
"image": "https://media.nature.com/lw1200/magazine-assets/d41586-024-01259-2/d41586-024-01259-2_27034294.jpg",
"content": "<div>\n <article>\n <p>Scientists have long known that <a target=\"_blank\" href=\"https://doi.org/10.1038/d41586-023-00509-z\">the brain plays a part in the immune system</a> — but how it does so has been a mystery. Now, scientists have identified cells in the brainstem that sense <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-021-01396-y\">immune cues from the periphery of the body</a> and act as master regulators of the body’s <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-024-00871-6\">inflammatory response</a>.</p>\n <div>\n <h2 id=\"access-options\">Access options</h2>\n <section><div>\n <p>\n Access Nature and 54 other Nature Portfolio journals\n </p>\n <p>\n Get Nature+, our best-value online-access subscription\n </p>\n <div>\n <p>\n <span>$32.99<span> / 30 days</span></span>\n </p>\n <p>cancel any time</p>\n </div>\n </div><div>\n <p>Subscribe to this journal</p>\n <p>\n Receive 51 print issues and online access\n </p>\n <div>\n <p>$199.00 per year</p>\n <p>only $3.90 per issue</p>\n </div>\n </div><div>\n <p>Rent or buy this article</p>\n <p>Prices vary by article type</p>\n <p><span>from</span>$1.95</p>\n <p><span>to</span>$39.95</p>\n </div><p>Prices may be subject to local taxes which are calculated during checkout</p></section>\n <h3>Additional access options:</h3>\n <ul>\n <li>\n <a target=\"_blank\" href=\"https://idp.nature.com/authorize/natureuser?client_id=grover&amp;redirect_uri=https%3A%2F%2Fwww.nature.com%2Farticles%2Fd41586-024-01259-2\">Log in</a>\n </li>\n <li>\n <a target=\"_blank\" href=\"https://www.springernature.com/gp/librarians/licensing/license-options\">Learn about institutional subscriptions</a>\n </li>\n <li>\n <a target=\"_blank\" href=\"https://support.nature.com/en/support/home\">Read our FAQs</a>\n </li>\n <li>\n <a target=\"_blank\" href=\"https://www.springernature.com/gp/contact\">Contact customer support</a>\n </li>\n </ul>\n </div>\n <p><em>doi: https://doi.org/10.1038/d41586-024-01259-2</em></p>\n <div><h2 id=\"Bib1\">References</h2></div>\n <h2 id=\"related-articles\">Related Articles</h2>\n <ul>\n <li>\n <p>\n <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-023-00509-z\">\n <img src=\"https://media.nature.com/lw100/magazine-assets/d41586-024-01259-2/d41586-024-01259-2_24096670.jpg\" />\n Your brain could be controlling how sick you get — and how you recover\n </a>\n </p>\n </li>\n <li>\n <p>\n <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-022-01502-8\">\n <img src=\"https://media.nature.com/lw100/magazine-assets/d41586-024-01259-2/d41586-024-01259-2_24045344.jpg\" />\n Guardians of the brain: how a special immune system protects our grey matter\n </a>\n </p>\n </li>\n <li>\n <p>\n <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-024-00169-7\">\n <img src=\"https://media.nature.com/lw100/magazine-assets/d41586-024-01259-2/d41586-024-01259-2_26671374.jpg\" />\n Can autoimmune diseases be cured? Scientists see hope at last\n </a>\n </p>\n </li>\n <li>\n <p>\n <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-023-00584-2\">\n <img src=\"https://media.nature.com/lw100/magazine-assets/d41586-024-01259-2/d41586-024-01259-2_24096666.jpg\" />\n Anxiety can be created by the body, mouse heart study suggests\n </a>\n </p>\n </li>\n </ul>\n <h2 id=\"subjects\">Subjects</h2>\n <ul>\n <li>\n <a target=\"_blank\" href=\"https://www.nature.com/subjects/brain\">Brain</a>\n </li>\n <li>\n <a target=\"_blank\" href=\"https://www.nature.com/subjects/immunology\">Immunology</a>\n </li>\n <li>\n <a target=\"_blank\" href=\"https://www.nature.com/subjects/neuroscience\">Neuroscience</a>\n </li>\n </ul>\n <section>\n <h2 id=\"tablist-heading\">Latest on:</h2>\n <ul>\n <li>\n <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-024-01259-2#latest-content-0-container\">Brain</a>\n </li>\n <li>\n <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-024-01259-2#latest-content-1-container\">Immunology</a>\n </li>\n <li>\n <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-024-01259-2#latest-content-2-container\">Neuroscience</a>\n </li>\n </ul>\n <section>\n <ul>\n <li>\n <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-026-01407-w\">\n <img src=\"https://images.nature.com/w140h79/magazine-assets/d41586-026-01407-w/d41586-026-01407-w_52356090.jpg\" />\n <p>Are attention spans really shrinking? What the science says</p>\n <p><span>News Feature</span> <span>06 MAY 26</span></p>\n </a>\n </li>\n <li>\n <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-026-01465-0\">\n <img src=\"https://images.nature.com/w140h79/magazine-assets/d41586-026-01465-0/d41586-026-01465-0_52376964.jpg\" />\n <p>Even the unconscious brain can learn — and predict what you’ll say next</p>\n <p><span>News</span> <span>06 MAY 26</span></p>\n </a>\n </li>\n <li>\n <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-026-01338-6\">\n <img src=\"https://images.nature.com/w140h79/magazine-assets/d41586-026-01338-6/d41586-026-01338-6_52322922.jpg\" />\n <p>New-found brain network is a ‘secret system’ made of helper cells</p>\n <p><span>News</span> <span>22 APR 26</span></p>\n </a>\n </li>\n </ul>\n </section>\n <section>\n <ul>\n <li>\n <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-026-01372-4\">\n <img src=\"https://images.nature.com/w140h79/magazine-assets/d41586-026-01372-4/d41586-026-01372-4_52356006.jpg\" />\n <p>The fightback against antimicrobial resistance starts at home</p>\n <p><span>Outlook</span> <span>13 MAY 26</span></p>\n </a>\n </li>\n <li>\n <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-026-01322-0\">\n <img src=\"https://images.nature.com/w140h79/magazine-assets/d41586-026-01322-0/d41586-026-01322-0_52406482.jpg\" />\n <p>Protective maternal gut instincts</p>\n <p><span>News &amp; Views</span> <span>13 MAY 26</span></p>\n </a>\n </li>\n <li>\n <a target=\"_blank\" href=\"https://www.nature.com/articles/s41586-026-10480-0\">\n <img src=\"https://media.nature.com/w140h79/springer-static/image/art%3A10.1038%2Fs41586-026-10480-0/MediaObjects/41586_2026_10480_Fig1_HTML.png\" />\n <p>Sustaining microglial reparative function enhances stroke recovery</p>\n <p><span>Article</span> <span>13 MAY 26</span></p>\n </a>\n </li>\n </ul>\n </section>\n <section>\n <ul>\n <li>\n <a target=\"_blank\" href=\"https://www.nature.com/articles/s41586-026-10510-x\">\n <img src=\"https://media.nature.com/w140h79/springer-static/image/art%3A10.1038%2Fs41586-026-10510-x/MediaObjects/41586_2026_10510_Fig1_HTML.png\" />\n <p>A synaptic locus of song learning</p>\n <p><span>Article</span> <span>13 MAY 26</span></p>\n </a>\n </li>\n <li>\n <a target=\"_blank\" href=\"https://www.nature.com/articles/s41586-026-10501-y\">\n <img src=\"https://media.nature.com/w140h79/springer-static/image/art%3A10.1038%2Fs41586-026-10501-y/MediaObjects/41586_2026_10501_Fig1_HTML.png\" />\n <p>Long-term editing of brain circuits using an engineered electrical synapse</p>\n <p><span>Article</span> <span>13 MAY 26</span></p>\n </a>\n </li>\n <li>\n <a target=\"_blank\" href=\"https://www.nature.com/articles/s41586-026-10481-z\">\n <img src=\"https://media.nature.com/w140h79/springer-static/image/art%3A10.1038%2Fs41586-026-10481-z/MediaObjects/41586_2026_10481_Fig1_HTML.png\" />\n <p>Subspace communication in the hippocampal–retrosplenial axis</p>\n <p><span>Article</span> <span>13 MAY 26</span></p>\n </a>\n </li>\n </ul>\n </section>\n</section>\n <div>\n <div>\n <h2>\n <img src=\"https://www.nature.com/static/images/logos/nature-careers-logo-3c89275050.svg\" alt=\"Nature Careers\" />\n </h2>\n </div>\n <h3>\n <a target=\"_blank\" href=\"https://www.nature.com/naturecareers/\">Jobs\n </a>\n </h3>\n <ul>\n <li>\n <div>\n <h4><a target=\"_blank\" href=\"https://www.nature.com/naturecareers/job/12859054/postdoctoral-fellow/?TrackID=62&amp;utm_source=widget&amp;utm_medium=referral&amp;utm_campaign=62\">Postdoctoral Fellow</a></h4>\n <div>\n <p>Postdoctoral Fellow focus on ferroic smart materials: shape-memory alloys, piezoelectric ceramics, and magnetostrictive materials, etc</p>\n <p>Ningbo, Zhejiang (CN)</p>\n <p>Center for Advanced Smart Materials (CASM), Yongjiang Laboratory (Y-Lab)</p>\n </div>\n </div>\n <p><img src=\"https://www.nature.com/naturecareers/getasset/0cd3afbf-67a2-42c0-ac85-bd7a22d1059f/\" />\n </p>\n </li>\n <li>\n <div>\n <h4><a target=\"_blank\" href=\"https://www.nature.com/naturecareers/job/12859052/principal-investigator-associate-professor/?TrackID=62&amp;utm_source=widget&amp;utm_medium=referral&amp;utm_campaign=62\">Principal Investigator/ Associate Professor</a></h4>\n <div>\n <p>PI &amp; Associate Professor class focus on innovative research about ferroic smart materials or technology transfer</p>\n <p>Ningbo, Zhejiang (CN)</p>\n <p>Center for Advanced Smart Materials (CASM), Yongjiang Laboratory (Y-Lab)</p>\n </div>\n </div>\n <p><img src=\"https://www.nature.com/naturecareers/getasset/0cd3afbf-67a2-42c0-ac85-bd7a22d1059f/\" />\n </p>\n </li>\n <li>\n <div>\n <h4><a target=\"_blank\" href=\"https://www.nature.com/naturecareers/job/12859169/scientific-editor/?TrackID=62&amp;utm_source=widget&amp;utm_medium=referral&amp;utm_campaign=62\">Scientific Editor</a></h4>\n <div>\n <p>The Scientific Editor plays a critical role in ensuring a high‑quality, efficient, and integrity‑driven peer review process.</p>\n <p>London - Hybrid working model</p>\n <p>Springer Nature Ltd</p>\n </div>\n </div>\n <p><img src=\"https://www.nature.com/naturecareers/getasset/7387bab3-756d-4666-8199-d6e4d0b97d0f/\" />\n </p>\n </li>\n <li>\n <div>\n <h4><a target=\"_blank\" href=\"https://www.nature.com/naturecareers/job/12859154/crag-director/?TrackID=62&amp;utm_source=widget&amp;utm_medium=referral&amp;utm_campaign=62\">CRAG Director</a></h4>\n <div>\n <p>CRAG is seeking applicants for Director with a distinguished record of scientific excellence, proven leadership and management experience.</p>\n <p>Universitat Autònoma de Barcelona (UAB), Bellaterra, Barcelona</p>\n <p>Centre de Recerca en Agrigenòmica (CRAG), Consorci CSIC – IRTA – UAB – UB</p>\n </div>\n </div>\n <p><img src=\"https://www.nature.com/naturecareers/getasset/db779c63-aac3-42df-901d-528c1f1d5ad0/\" />\n </p>\n </li>\n <li>\n <div>\n <h4><a target=\"_blank\" href=\"https://www.nature.com/naturecareers/job/12859149/associate-or-senior-editor-nature-materials/?TrackID=62&amp;utm_source=widget&amp;utm_medium=referral&amp;utm_campaign=62\">Associate or Senior Editor, Nature Materials</a></h4>\n <div>\n <p>Job Title: Associate or Senior Editor, Nature Materials Locations: Shanghai, Beijing, Milan or Pune - hybrid working model Application Deadline: Ju...</p>\n <p>Shanghai, Beijing, Milan or Pune - hybrid working model</p>\n <p>Springer Nature Ltd</p>\n </div>\n </div>\n <p><img src=\"https://www.nature.com/naturecareers/getasset/7387bab3-756d-4666-8199-d6e4d0b97d0f/\" />\n </p>\n </li>\n </ul>\n </div>\n </article>\n </div>",
"author": "Guglielmi, Giorgia",
"favicon": "https://www.nature.com/static/images/favicons/nature/favicon.ico",
"source": "nature.com",
"published": "2024-05-01",
"ttr": 96,
"type": "article"
}