Found: The dial in the brain that controls the immune system

{
  "by": "andreareina",
  "descendants": 4,
  "id": 40243417,
  "kids": [
    40243718,
    40244904,
    40245202
  ],
  "score": 45,
  "time": 1714703500,
  "title": "Found: The dial in the brain that controls the immune system",
  "type": "story",
  "url": "https://www.nature.com/articles/d41586-024-01259-2"
}

{
  "author": "Giorgia Guglielmi",
  "date": "2024-05-01T00:00:00.000Z",
  "description": "Scientists identify the brain cells that regulate inflammation, and pinpoint how they keep tabs on the immune response.",
  "image": "https://media.nature.com/lw1200/magazine-assets/d41586-024-01259-2/d41586-024-01259-2_27034294.jpg",
  "logo": null,
  "publisher": "Nature",
  "title": "Found: the dial in the brain that controls the immune system",
  "url": "https://www.nature.com/articles/d41586-024-01259-2"
}

{
  "url": "https://www.nature.com/articles/d41586-024-01259-2",
  "title": "Found: the dial in the brain that controls the immune system",
  "description": "Scientists identify the brain cells that regulate inflammation, and pinpoint how they keep tabs on the immune response. Scientists identify the brain cells that regulate inflammation, and pinpoint how they keep tabs on the immune response.",
  "links": [
    "https://www.nature.com/articles/d41586-024-01259-2"
  ],
  "image": "https://media.nature.com/lw1200/magazine-assets/d41586-024-01259-2/d41586-024-01259-2_27034294.jpg",
  "content": "<div>\n                    <article>\n<div>\n        <div>\n            <ul>\n                <li><span>NEWS</span></li>\n                <li>01 May 2024</li>\n            </ul>\n            <div>\n                <p>\n                    Scientists identify the brain cells that regulate inflammation, and pinpoint how they keep tabs on the immune response.\n                </p>\n            </div>\n        </div>\n            <div>\n                <p><span>By</span></p><ul>\n        <li>\n            <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-024-01259-2#author-0\">\n                Giorgia Guglielmi</a><sup><a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-024-01259-2#Aff0\">0</a></sup></li>\n</ul>\n<div>\n    <ol>\n            <li>\n                    <span>Giorgia Guglielmi</span>\n                    <ol>\n                        <li>\n                            <p>Giorgia Guglielmi is a science journalist in Basel, Switzerland.</p>\n                        </li>\n                    </ol>\n                    <div>\n                            <div><p><a target=\"_blank\" href=\"https://www.nature.com/search?author=Giorgia+Guglielmi\">View author publications</a></p></div>\n                            <div>\n                                <p>\n                                    <span>Search author on:</span>\n                                    <span><a target=\"_blank\" href=\"http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&amp;term=Giorgia+Guglielmi\">PubMed</a>\n                                    <span> </span><a target=\"_blank\" href=\"https://scholar.google.co.uk/scholar?as_q=&amp;btnG=Search+Scholar&amp;as_sauthors=%22Giorgia%2BGuglielmi%22\">Google Scholar</a>\n                                    </span></p>\n                            </div>\n                       </div>\n            </li>\n    </ol>\n</div>\n            </div>\n    <div>\n        <ul>\n    <li>\n        <a target=\"_blank\" href=\"mailto:?subject=Found:%20the%20dial%20in%20the%20brain%20that%20controls%20the%20immune%20system&amp;body=https%3A%2F%2Fwww.nature.com%2Farticles%2Fd41586-024-01259-2\">\n            <span>Email</span>\n        </a>\n    </li>\n    <li>\n        <a target=\"_blank\" href=\"https://bsky.app/intent/compose?text=Found%3A+the+dial+in+the+brain+that+controls+the+immune+system%20https%3A%2F%2Fwww.nature.com%2Farticles%2Fd41586-024-01259-2\">\n            <span>Bluesky</span>\n        </a>\n    </li>\n    <li>\n        <a target=\"_blank\" href=\"https://www.facebook.com/sharer.php?u=https%3A%2F%2Fwww.nature.com%2Farticles%2Fd41586-024-01259-2&amp;t=Found%3A+the+dial+in+the+brain+that+controls+the+immune+system\">\n            <span>Facebook</span>\n        </a>\n    </li>\n    <li>\n        <a target=\"_blank\" href=\"https://www.linkedin.com/shareArticle?text=Found%3A+the+dial+in+the+brain+that+controls+the+immune+system&amp;url=https%3A%2F%2Fwww.nature.com%2Farticles%2Fd41586-024-01259-2\">\n            <span>LinkedIn</span>\n        </a>\n    </li>\n    <li>\n        <a target=\"_blank\" href=\"https://www.reddit.com/submit?title=Found%3A+the+dial+in+the+brain+that+controls+the+immune+system&amp;url=https%3A%2F%2Fwww.nature.com%2Farticles%2Fd41586-024-01259-2\">\n            <span>Reddit</span>\n        </a>\n    </li>\n    <li>\n        <a target=\"_blank\" href=\"https://wa.me/?text=Found%3A+the+dial+in+the+brain+that+controls+the+immune+system%20https%3A%2F%2Fwww.nature.com%2Farticles%2Fd41586-024-01259-2\">\n            <span>Whatsapp</span>\n        </a>\n    </li>\n    <li>\n        <a target=\"_blank\" href=\"https://twitter.com/intent/tweet?text=Found%3A+the+dial+in+the+brain+that+controls+the+immune+system&amp;url=https%3A%2F%2Fwww.nature.com%2Farticles%2Fd41586-024-01259-2\">\n            <span>X</span>\n        </a>\n    </li>\n</ul>\n    </div>\n</div>\n                    <div>\n            <p>\n                <a target=\"_blank\" href=\"https://wayf.springernature.com/?redirect_uri=https%3A%2F%2Fwww.nature.com%2Farticles%2Fd41586-024-01259-2\">\n                    <span>Access through your institution</span>\n                </a>\n            </p>\n                <div>\n                    <p><a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-024-01259-2#access-options\">\n                        <span>Buy or subscribe</span>\n                    </a>\n                </p></div>\n        </div>\n                    <p>Scientists have long known that <a target=\"_blank\" href=\"https://doi.org/10.1038/d41586-023-00509-z\">the brain plays a part in the immune system</a> — but how it does so has been a mystery. Now, scientists have identified cells in the brainstem that sense <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-021-01396-y\">immune cues from the periphery of the body</a> and act as master regulators of the body’s <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-024-00871-6\">inflammatory response</a>.</p>\n                    <div>\n                        <h2 id=\"access-options\">Access options</h2>\n        <div>\n            <p>\n                <a target=\"_blank\" href=\"https://wayf.springernature.com/?redirect_uri=https%3A%2F%2Fwww.nature.com%2Farticles%2Fd41586-024-01259-2\">\n                    <span>Access through your institution</span>\n                </a>\n            </p>\n        </div>\n    <section><div>\n      <p>\n        Access Nature and 54 other Nature Portfolio journals\n      </p>\n      <p>\n        Get Nature+, our best-value online-access subscription\n      </p>\n      <div>\n        <p>\n          <span>$32.99<span> / 30 days</span></span>\n        </p>\n        <p>cancel any time</p>\n      </div>\n      <div>\n        <p><a target=\"_blank\" href=\"https://shop-amers.nature.com/products/plus/?region=US\"><span>Learn more</span></a>\n      </p></div>\n    </div><div>\n      <p>Subscribe to this journal</p>\n      <p>\n        Receive 51 print issues and online access\n      </p>\n    <div>\n      <p>$199.00 per year</p>\n      <p>only $3.90 per issue</p>\n    </div>\n    <div>\n      <p><a target=\"_blank\" href=\"https://www.nature.com/nature/subscribe\"><span>Learn more</span></a>\n    </p></div>\n    </div><div>\n      <p>Rent or buy this article</p>\n      <p>Prices vary by article type</p>\n      <p><span>from</span>$1.95</p>\n      <p><span>to</span>$39.95</p>\n      <div>\n        <p><a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-024-01259-2.epdf?no_publisher_access=1&amp;r3_referer=nature\"><span>Learn more</span></a>\n      </p></div>\n    </div><p>Prices may be subject to local taxes which are calculated during checkout</p></section>\n    <h3>Additional access options:</h3>\n    <ul>\n        <li>\n            <a target=\"_blank\" href=\"https://idp.nature.com/authorize/natureuser?client_id=grover&amp;redirect_uri=https%3A%2F%2Fwww.nature.com%2Farticles%2Fd41586-024-01259-2\">Log in</a>\n        </li>\n        <li>\n            <a target=\"_blank\" href=\"https://www.springernature.com/gp/librarians/licensing/license-options\">Learn about institutional subscriptions</a>\n        </li>\n        <li>\n            <a target=\"_blank\" href=\"https://support.nature.com/en/support/home\">Read our FAQs</a>\n        </li>\n        <li>\n            <a target=\"_blank\" href=\"https://www.springernature.com/gp/contact\">Contact customer support</a>\n        </li>\n    </ul>\n                    </div>\n                <p><em>doi: https://doi.org/10.1038/d41586-024-01259-2</em></p>\n            <div><h2 id=\"Bib1\">References</h2><div><ol><li><p>Jin, H., Li, M., Jeong, E., Castro-Martinez, F. &amp; Zuker, C. S. <i>Nature</i> https://doi.org/10.1038/s41586-024-07469-y (2024).</p><p><a target=\"_blank\" href=\"https://doi.org/10.1038%2Fs41586-024-07469-y\">Article</a> \n    <a target=\"_blank\" href=\"http://scholar.google.com/scholar_lookup?&amp;title=&amp;journal=Nature&amp;doi=10.1038%2Fs41586-024-07469-y&amp;publication_year=2024&amp;author=Jin%2CH.&amp;author=Li%2CM.&amp;author=Jeong%2CE.&amp;author=Castro-Martinez%2CF.&amp;author=Zuker%2CC.%20S.\">\n                    Google Scholar</a> \n                </p></li></ol><p><a target=\"_blank\" href=\"https://citation-needed.springer.com/v2/references/10.1038/d41586-024-01259-2?format=refman&amp;flavour=references\">Download references</a></p></div></div>\n                <div>\n                    <p><a target=\"_blank\" href=\"https://s100.copyright.com/AppDispatchServlet?title=Found%3A%20the%20dial%20in%20the%20brain%20that%20controls%20the%20immune%20system&amp;author=Giorgia%20Guglielmi&amp;contentID=10.1038%2Fd41586-024-01259-2&amp;copyright=Springer%20Nature%20Limited&amp;publication=0028-0836&amp;publicationDate=2024-05-01&amp;publisherName=SpringerNature&amp;orderBeanReset=true\">Reprints and permissions</a></p>\n                </div>\n                <h2 id=\"related-articles\">Related Articles</h2>\n    <ul>\n            <li>\n                <p>\n                    <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-023-00509-z\">\n                            <img src=\"https://media.nature.com/lw100/magazine-assets/d41586-024-01259-2/d41586-024-01259-2_24096670.jpg\" />\n                        Your brain could be controlling how sick you get — and how you recover\n                    </a>\n                </p>\n            </li>\n            <li>\n                <p>\n                    <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-022-01502-8\">\n                            <img src=\"https://media.nature.com/lw100/magazine-assets/d41586-024-01259-2/d41586-024-01259-2_24045344.jpg\" />\n                        Guardians of the brain: how a special immune system protects our grey matter\n                    </a>\n                </p>\n            </li>\n            <li>\n                <p>\n                    <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-024-00169-7\">\n                            <img src=\"https://media.nature.com/lw100/magazine-assets/d41586-024-01259-2/d41586-024-01259-2_26671374.jpg\" />\n                        Can autoimmune diseases be cured? Scientists see hope at last\n                    </a>\n                </p>\n            </li>\n            <li>\n                <p>\n                    <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-023-00584-2\">\n                            <img src=\"https://media.nature.com/lw100/magazine-assets/d41586-024-01259-2/d41586-024-01259-2_24096666.jpg\" />\n                        Anxiety can be created by the body, mouse heart study suggests\n                    </a>\n                </p>\n            </li>\n    </ul>\n                <h2 id=\"subjects\">Subjects</h2>\n    <ul>\n            <li>\n                <a target=\"_blank\" href=\"https://www.nature.com/subjects/brain\">Brain</a>\n            </li>\n            <li>\n                <a target=\"_blank\" href=\"https://www.nature.com/subjects/immunology\">Immunology</a>\n            </li>\n            <li>\n                <a target=\"_blank\" href=\"https://www.nature.com/subjects/neuroscience\">Neuroscience</a>\n            </li>\n    </ul>\n            <section>\n    <h2 id=\"tablist-heading\">Latest on:</h2>\n    <ul>\n            <li>\n                <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-024-01259-2#latest-content-0-container\">Brain</a>\n            </li>\n            <li>\n                <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-024-01259-2#latest-content-1-container\">Immunology</a>\n            </li>\n            <li>\n                <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-024-01259-2#latest-content-2-container\">Neuroscience</a>\n            </li>\n    </ul>\n    <section>\n        <ul>\n                <li>\n                    <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-026-00062-5\">\n                            <img src=\"https://images.nature.com/w140h79/magazine-assets/d41586-026-00062-5/d41586-026-00062-5_51926634.jpg\" />\n                        <p>Can’t get motivated? This brain circuit might explain why — and it can be turned off</p>\n                        <p><span>News</span> <span>09 JAN 26</span></p>\n                    </a>\n                </li>\n                <li>\n                    <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-025-03987-5\">\n                            <img src=\"https://images.nature.com/w140h79/magazine-assets/d41586-025-03987-5/d41586-025-03987-5_51848894.png\" />\n                        <p>Chronic pain could be eased by uncoupling the sensory and emotional experiences</p>\n                        <p><span>News &amp; Views</span> <span>07 JAN 26</span></p>\n                    </a>\n                </li>\n                <li>\n                    <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-025-04133-x\">\n                            <img src=\"https://images.nature.com/w140h79/magazine-assets/d41586-025-04133-x/d41586-025-04133-x_51836886.jpg\" />\n                        <p>How common is Alzheimer’s? Blood-test study holds surprises</p>\n                        <p><span>News</span> <span>17 DEC 25</span></p>\n                    </a>\n                </li>\n        </ul>\n    </section>\n    <section>\n        <ul>\n                <li>\n                    <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-026-00073-2\">\n                            <img src=\"https://images.nature.com/w140h79/magazine-assets/d41586-026-00073-2/d41586-026-00073-2_51939178.jpg\" />\n                        <p>Making progress on global health will need high-quality evidence</p>\n                        <p><span>Editorial</span> <span>15 JAN 26</span></p>\n                    </a>\n                </li>\n                <li>\n                    <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-026-00082-1\">\n                            <img src=\"https://images.nature.com/w140h79/magazine-assets/d41586-026-00082-1/d41586-026-00082-1_51939362.jpg\" />\n                        <p>The infection enigma: why some people die from typically harmless germs</p>\n                        <p><span>News Feature</span> <span>14 JAN 26</span></p>\n                    </a>\n                </li>\n                <li>\n                    <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-026-00086-x\">\n                            <img src=\"https://images.nature.com/w140h79/magazine-assets/d41586-026-00086-x/d41586-026-00086-x_51926346.jpg\" />\n                        <p>Six steps to protect researchers’ digital security</p>\n                        <p><span>Technology Feature</span> <span>14 JAN 26</span></p>\n                    </a>\n                </li>\n        </ul>\n    </section>\n    <section>\n        <ul>\n                <li>\n                    <a target=\"_blank\" href=\"https://www.nature.com/articles/s41586-025-09958-0\">\n                            <img src=\"https://media.nature.com/w140h79/springer-static/image/art%3A10.1038%2Fs41586-025-09958-0/MediaObjects/41586_2025_9958_Fig1_HTML.png\" />\n                        <p>Predictive coding of reward in the hippocampus</p>\n                        <p><span>Article</span> <span>14 JAN 26</span></p>\n                    </a>\n                </li>\n                <li>\n                    <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-026-00062-5\">\n                            <img src=\"https://images.nature.com/w140h79/magazine-assets/d41586-026-00062-5/d41586-026-00062-5_51926634.jpg\" />\n                        <p>Can’t get motivated? This brain circuit might explain why — and it can be turned off</p>\n                        <p><span>News</span> <span>09 JAN 26</span></p>\n                    </a>\n                </li>\n                <li>\n                    <a target=\"_blank\" href=\"https://www.nature.com/articles/s41586-025-09902-2\">\n                            <img src=\"https://media.nature.com/w140h79/springer-static/image/art%3A10.1038%2Fs41586-025-09902-2/MediaObjects/41586_2025_9902_Fig1_HTML.png\" />\n                        <p>Prefrontal neural geometry of learned cues guides motivated behaviours</p>\n                        <p><span>Article</span> <span>07 JAN 26</span></p>\n                    </a>\n                </li>\n        </ul>\n    </section>\n</section>\n            <div>\n        <div>\n            <h2>\n                <img src=\"https://www.nature.com/static/images/logos/nature-careers-logo-f6ff1c1c64.svg\" alt=\"Nature Careers\" />\n            </h2>\n        </div>\n        <h3>\n            <a target=\"_blank\" href=\"https://www.nature.com/naturecareers/\">Jobs\n            </a>\n        </h3>\n        <ul>\n                <li>\n                    <div>\n                        <h4><a target=\"_blank\" href=\"https://www.nature.com/naturecareers/job/12852696/associate-publisher-or-publisher/?TrackID=62&amp;utm_source=widget&amp;utm_medium=referral&amp;utm_campaign=62\">Associate Publisher or Publisher</a></h4>\n                        <div>\n                            <p>Title: Associate Publisher or Publisher Location: Shanghai, Beijing, Pune - hybrid working model Closing date: February 4th, 2026   About Springer ...</p>\n                            <p>Shanghai, Beijing, Pune - hybrid working model</p>\n                            <p>Springer Nature Ltd</p>\n                        </div>\n                    </div>\n                        <p><img src=\"https://www.nature.com/naturecareers/getasset/7387bab3-756d-4666-8199-d6e4d0b97d0f/\" />\n                        </p>\n                </li>\n                <li>\n                    <div>\n                        <h4><a target=\"_blank\" href=\"https://www.nature.com/naturecareers/job/12844901/seeking-talents-faculty-positions-in-ai-at-institute-of-automation-chinese-academy-of-sciences/?TrackID=62&amp;utm_source=widget&amp;utm_medium=referral&amp;utm_campaign=62\">Seeking Talents: Faculty Positions in AI at Institute of Automation, Chinese Academy of Sciences</a></h4>\n                        <div>\n                            <p>Full/Associate/Assistant Professor Positions of State Key Labs are opening.</p>\n                            <p>Beijing, Nanjing and Wuhan</p>\n                            <p>Institute of Automation, Chinese Academy of Sciences</p>\n                        </div>\n                    </div>\n                        <p><img src=\"https://www.nature.com/naturecareers/getasset/4b48e3ae-6133-4141-a389-ff7d125e8bcd/\" />\n                        </p>\n                </li>\n                <li>\n                    <div>\n                        <h4><a target=\"_blank\" href=\"https://www.nature.com/naturecareers/job/12849370/tenure-track-faculty-positions-in-theoretical-particle-physics-and-cosmology/?TrackID=62&amp;utm_source=widget&amp;utm_medium=referral&amp;utm_campaign=62\">Tenure-track Faculty Positions in Theoretical Particle Physics and Cosmology</a></h4>\n                        <div>\n                            <p>Theoretical Particle Physics and Cosmology, tenure-track, HKUST</p>\n                            <p>Hong Kong (HK)</p>\n                            <p>Department of Physics, The Hong Kong University of Science &amp; Technology (HKUST)</p>\n                        </div>\n                    </div>\n                        <p><img src=\"https://www.nature.com/naturecareers/getasset/51bd8832-7e8f-4885-a771-9b1532da9f11/\" />\n                        </p>\n                </li>\n                <li>\n                    <div>\n                        <h4><a target=\"_blank\" href=\"https://www.nature.com/naturecareers/job/12849369/tenure-track-faculty-positions-in-observational-cosmology/?TrackID=62&amp;utm_source=widget&amp;utm_medium=referral&amp;utm_campaign=62\">Tenure-track Faculty Positions in Observational Cosmology</a></h4>\n                        <div>\n                            <p>Observational Cosmology, HKUST, tenure-track</p>\n                            <p>Hong Kong (HK)</p>\n                            <p>Department of Physics, The Hong Kong University of Science &amp; Technology (HKUST)</p>\n                        </div>\n                    </div>\n                        <p><img src=\"https://www.nature.com/naturecareers/getasset/51bd8832-7e8f-4885-a771-9b1532da9f11/\" />\n                        </p>\n                </li>\n                <li>\n                    <div>\n                        <h4><a target=\"_blank\" href=\"https://www.nature.com/naturecareers/job/12849368/tenure-track-faculty-positions-in-experimental-particle-physics/?TrackID=62&amp;utm_source=widget&amp;utm_medium=referral&amp;utm_campaign=62\">Tenure-track Faculty Positions in Experimental Particle Physics</a></h4>\n                        <div>\n                            <p>Experimental Particle Physics, HKUST, tenure-track</p>\n                            <p>Hong Kong (HK)</p>\n                            <p>Department of Physics, The Hong Kong University of Science &amp; Technology (HKUST)</p>\n                        </div>\n                    </div>\n                        <p><img src=\"https://www.nature.com/naturecareers/getasset/51bd8832-7e8f-4885-a771-9b1532da9f11/\" />\n                        </p>\n                </li>\n        </ul>\n            </div>\n                    </article>\n                </div>",
  "author": "Guglielmi, Giorgia",
  "favicon": "https://www.nature.com/static/images/favicons/nature/favicon.ico",
  "source": "nature.com",
  "published": "2024-05-01",
  "ttr": 115,
  "type": "article"
}