Found: The dial in the brain that controls the immune system

https://www.nature.com/articles/d41586-024-01259-2

Scientists have long known that the brain plays a part in the immune system — but how it does so has been a mystery. Now, scientists have identified cells in the brainstem that sense immune cues from the periphery of the body and act as master regulators of the body’s inflammatory response.

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doi: https://doi.org/10.1038/d41586-024-01259-2

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"author": "Giorgia Guglielmi",
"date": "2024-05-01T00:00:00.000Z",
"description": "Scientists identify the brain cells that regulate inflammation, and pinpoint how they keep tabs on the immune response.",
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"title": "Found: the dial in the brain that controls the immune system",
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{
"url": "https://www.nature.com/articles/d41586-024-01259-2",
"title": "Found: the dial in the brain that controls the immune system",
"description": "Scientists identify the brain cells that regulate inflammation, and pinpoint how they keep tabs on the immune response. Scientists identify the brain cells that regulate inflammation, and pinpoint how they keep tabs on the immune response.",
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"content": "<div>\n <article>\n <p>Scientists have long known that <a target=\"_blank\" href=\"https://doi.org/10.1038/d41586-023-00509-z\">the brain plays a part in the immune system</a> — but how it does so has been a mystery. Now, scientists have identified cells in the brainstem that sense <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-021-01396-y\">immune cues from the periphery of the body</a> and act as master regulators of the body’s <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-024-00871-6\">inflammatory response</a>.</p>\n <div>\n <h2 id=\"access-options\">Access options</h2>\n <section><div>\n <p>\n Access Nature and 54 other Nature Portfolio journals\n </p>\n <p>\n Get Nature+, our best-value online-access subscription\n </p>\n <div>\n <p>\n <span>$32.99<span> / 30 days</span></span>\n </p>\n <p>cancel any time</p>\n </div>\n </div><div>\n <p>Subscribe to this journal</p>\n <p>\n Receive 52 print issues and online access\n </p>\n <div>\n <p>$199.00 per year</p>\n <p>only $3.83 per issue</p>\n </div>\n </div><div>\n <p>Rent or buy this article</p>\n <p>Prices vary by article type</p>\n <p><span>from</span>$1.95</p>\n <p><span>to</span>$39.95</p>\n </div><p>Prices may be subject to local taxes which are calculated during checkout</p></section>\n <h3>Additional access options:</h3>\n <ul>\n <li>\n <a target=\"_blank\" href=\"https://idp.nature.com/authorize/natureuser?client_id=grover&amp;redirect_uri=https%3A%2F%2Fwww.nature.com%2Farticles%2Fd41586-024-01259-2\">Log in</a>\n </li>\n <li>\n <a target=\"_blank\" href=\"https://www.springernature.com/gp/librarians/licensing/license-options\">Learn about institutional subscriptions</a>\n </li>\n <li>\n <a target=\"_blank\" href=\"https://support.nature.com/en/support/home\">Read our FAQs</a>\n </li>\n <li>\n <a target=\"_blank\" href=\"https://www.springernature.com/gp/contact\">Contact customer support</a>\n </li>\n </ul>\n </div>\n <p><em>doi: https://doi.org/10.1038/d41586-024-01259-2</em></p>\n <div><h2 id=\"Bib1\">References</h2></div>\n <h2 id=\"related-articles\">Related Articles</h2>\n <ul>\n <li>\n <p>\n <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-023-00509-z\">\n <img src=\"https://media.nature.com/lw100/magazine-assets/d41586-024-01259-2/d41586-024-01259-2_24096670.jpg\" />\n Your brain could be controlling how sick you get — and how you recover\n </a>\n </p>\n </li>\n <li>\n <p>\n <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-022-01502-8\">\n <img src=\"https://media.nature.com/lw100/magazine-assets/d41586-024-01259-2/d41586-024-01259-2_24045344.jpg\" />\n Guardians of the brain: how a special immune system protects our grey matter\n </a>\n </p>\n </li>\n <li>\n <p>\n <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-024-00169-7\">\n <img src=\"https://media.nature.com/lw100/magazine-assets/d41586-024-01259-2/d41586-024-01259-2_26671374.jpg\" />\n Can autoimmune diseases be cured? Scientists see hope at last\n </a>\n </p>\n </li>\n <li>\n <p>\n <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-023-00584-2\">\n <img src=\"https://media.nature.com/lw100/magazine-assets/d41586-024-01259-2/d41586-024-01259-2_24096666.jpg\" />\n Anxiety can be created by the body, mouse heart study suggests\n </a>\n </p>\n </li>\n </ul>\n <h2 id=\"subjects\">Subjects</h2>\n <ul>\n <li>\n <a target=\"_blank\" href=\"https://www.nature.com/subjects/brain\">Brain</a>\n </li>\n <li>\n <a target=\"_blank\" href=\"https://www.nature.com/subjects/immunology\">Immunology</a>\n </li>\n <li>\n <a target=\"_blank\" href=\"https://www.nature.com/subjects/neuroscience\">Neuroscience</a>\n </li>\n </ul>\n <section>\n <h2 id=\"tablist-heading\">Latest on:</h2>\n <ul>\n <li>\n <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-024-01259-2#latest-content-0-container\">Brain</a>\n </li>\n <li>\n <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-024-01259-2#latest-content-1-container\">Immunology</a>\n </li>\n <li>\n <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-024-01259-2#latest-content-2-container\">Neuroscience</a>\n </li>\n </ul>\n <section>\n <ul>\n <li>\n <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-026-01922-w\">\n <img src=\"https://images.nature.com/w140h79/magazine-assets/d41586-026-01922-w/d41586-026-01922-w_52673372.jpg\" />\n <p>How the brain builds sentences, neuron by neuron</p>\n <p><span>News</span> <span>17 JUN 26</span></p>\n </a>\n </li>\n <li>\n <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-026-01458-z\">\n <img src=\"https://images.nature.com/w140h79/magazine-assets/d41586-026-01458-z/d41586-026-01458-z_52398514.jpg\" />\n <p>How the connection between lung cancer and the brain could lead to better treatments</p>\n <p><span>Outlook</span> <span>27 MAY 26</span></p>\n </a>\n </li>\n <li>\n <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-026-01618-1\">\n <img src=\"https://images.nature.com/w140h79/magazine-assets/d41586-026-01618-1/d41586-026-01618-1_52441858.jpg\" />\n <p>Memory on trial: the new science of when to trust eyewitness testimony</p>\n <p><span>News Feature</span> <span>27 MAY 26</span></p>\n </a>\n </li>\n </ul>\n </section>\n <section>\n <ul>\n <li>\n <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-026-01925-7\">\n <img src=\"https://images.nature.com/w140h79/magazine-assets/d41586-026-01925-7/d41586-026-01925-7_52717924.jpg\" />\n <p>Stem cells banish severe autoimmune disease for 15 years</p>\n <p><span>News</span> <span>19 JUN 26</span></p>\n </a>\n </li>\n <li>\n <a target=\"_blank\" href=\"https://www.nature.com/articles/s41586-026-10634-0\">\n <img src=\"https://media.nature.com/w140h79/springer-static/image/art%3A10.1038%2Fs41586-026-10634-0/MediaObjects/41586_2026_10634_Fig1_HTML.png\" />\n <p>Mutation-dependent responses to sleep and exercise in clonal haematopoiesis</p>\n <p><span>Article</span> <span>10 JUN 26</span></p>\n </a>\n </li>\n <li>\n <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-026-01825-w\">\n <img src=\"https://images.nature.com/w140h79/magazine-assets/d41586-026-01825-w/d41586-026-01825-w_52515892.jpg\" />\n <p>TB vaccine from the 1920s shows promise in diabetes trial</p>\n <p><span>News</span> <span>09 JUN 26</span></p>\n </a>\n </li>\n </ul>\n </section>\n <section>\n <ul>\n <li>\n <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-026-01922-w\">\n <img src=\"https://images.nature.com/w140h79/magazine-assets/d41586-026-01922-w/d41586-026-01922-w_52673372.jpg\" />\n <p>How the brain builds sentences, neuron by neuron</p>\n <p><span>News</span> <span>17 JUN 26</span></p>\n </a>\n </li>\n <li>\n <a target=\"_blank\" href=\"https://www.nature.com/articles/d41586-026-01705-3\">\n <img src=\"https://images.nature.com/w140h79/magazine-assets/d41586-026-01705-3/d41586-026-01705-3_52668450.jpg\" />\n <p>Navigating a crowded developing brain leaves neurons with broken DNA</p>\n <p><span>News &amp; 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"author": "Guglielmi, Giorgia",
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"source": "nature.com",
"published": "2024-05-01",
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